abstract：BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...

journal_title：British journal of cancer

authors： Ueno K,Hirata H,Shahryari V,Deng G,Tanaka Y,Tabatabai ZL,Hinoda Y,Dahiya R

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) diagnoses and disease-specific survival (DSS) vary between ethnic groups in the United States. However, few studies have assessed differences among Asian subgroups. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with invasive CRC...

journal_title：British journal of cancer

authors： Yi M,Xu J,Liu P,Chang GJ,Du XL,Hu CY,Song Y,He J,Ren Y,Wei Y,Yang J,Hunt KK,Li X

更新日期：2013-04-16 00:00:00

abstract：BACKGROUND:Bladder cancer (BC) predominantly affects the elderly and is often the cause of death among patients with muscle-invasive disease. Clinicians lack quantitative estimates of competing mortality risks when considering treatments for BC. Our aim was to determine the bladder cancer-specific mortality (CSM) rate ...

journal_title：British journal of cancer

authors： Noon AP,Albertsen PC,Thomas F,Rosario DJ,Catto JW

更新日期：2013-04-16 00:00:00

abstract：BACKGROUND:The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). METHODS:MIA2 role was examined by immunohistochemistry of human OSCCs and knockdown studies using human 3 OSCC cell lines with MIA2 expression. RESULTS:MIA2 expression was observed in 62 (66.7%) of ...

journal_title：British journal of cancer

authors： Kurihara M,Kirita T,Sasahira T,Ohmori H,Matsushima S,Yamamoto K,Bosserhoff AK,Kuniyasu H

更新日期：2013-04-16 00:00:00

abstract：BACKGROUND:Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations. Accordingly, many of the genes whose expression is altered following immortalisation are those for which epigenetic si...

journal_title：British journal of cancer

authors： De Faveri LE,Hurst CD,Platt FM,Taylor CF,Roulson JA,Sanchez-Carbayo M,Knowles MA,Chapman EJ

更新日期：2013-04-02 00:00:00

abstract：BACKGROUND:Breast cancer 1, early onset (BRCA1) is a tumour-suppressor gene associated with familial epithelial ovarian cancer (EOC). Reduced BRCA1 expression is associated with enhanced sensitivity to platinum-based chemotherapy. We sought to examine the prognostic relevance of BRCA1 expression in EOC patients treated...

journal_title：British journal of cancer

authors： Lesnock JL,Darcy KM,Tian C,Deloia JA,Thrall MM,Zahn C,Armstrong DK,Birrer MJ,Krivak TC

更新日期：2013-04-02 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) testing in oropharyngeal squamous cell carcinoma (OPSCC) is now advocated. Demonstration of transcriptionally active high-risk HPV (HR-HPV) in fresh tumour tissue is considered to be the analytical 'gold standard'. Clinical testing has focused on formalin-fixed paraffin-embedded (F...

journal_title：British journal of cancer

authors： Schache AG,Liloglou T,Risk JM,Jones TM,Ma XJ,Wang H,Bui S,Luo Y,Sloan P,Shaw RJ,Robinson M

更新日期：2013-04-02 00:00:00

abstract：BACKGROUND:Clear cell renal cancer frequently harbours von Hippel-Lindau (VHL) gene mutations, leading to stabilisation of the hypoxia-inducible factors (HIFs) and expression of their target genes. We investigated HIF-1 and HIF-2 in the regulation of microRNA-210 (miR-210), and its clinical relevance in renal tumours. ...

journal_title：British journal of cancer

authors： McCormick RI,Blick C,Ragoussis J,Schoedel J,Mole DR,Young AC,Selby PJ,Banks RE,Harris AL

更新日期：2013-03-19 00:00:00

abstract：BACKGROUND:This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and preliminary activity of p28 in patients with p53(+) metastatic solid tumours. METHODS:A total of 15 patients were administered p28 i....

journal_title：British journal of cancer

authors： Warso MA,Richards JM,Mehta D,Christov K,Schaeffer C,Rae Bressler L,Yamada T,Majumdar D,Kennedy SA,Beattie CW,Das Gupta TK

更新日期：2013-03-19 00:00:00

abstract：BACKGROUND:The host immune reaction is represented by immune/inflammatory cell infiltrates. Here we systematically analysed tumour-infiltrating immune/inflammatory cells in pancreatic ductal carcinoma (PDC) and evaluated their clinicopathological impact. METHODS:Using immunohistochemistry, we examined tumour-infiltrat...

journal_title：British journal of cancer

authors： Ino Y,Yamazaki-Itoh R,Shimada K,Iwasaki M,Kosuge T,Kanai Y,Hiraoka N

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, incr...

journal_title：British journal of cancer

authors： Pervin S,Tran L,Urman R,Braga M,Parveen M,Li SA,Chaudhuri G,Singh R

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:The United Kingdom performs poorly in international comparisons of colorectal cancer survival with much of the deficit owing to high numbers of deaths close to the time of diagnosis. This retrospective cohort study investigates the patient, tumour and treatment characteristics of those who die in the first y...

journal_title：British journal of cancer

authors： Downing A,Aravani A,Macleod U,Oliver S,Finan PJ,Thomas JD,Quirke P,Wilkinson JR,Morris EJ

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:In metastatic colorectal cancer (mCRC), KRAS is the only validated biomarker used to select patients for administration of epidermal growth factor receptor (EGFR)-targeted therapies. To identify additional predictive markers, we investigated the importance of HER2, the primary EGFR dimerisation partner, in t...

journal_title：British journal of cancer

authors： Martin V,Landi L,Molinari F,Fountzilas G,Geva R,Riva A,Saletti P,De Dosso S,Spitale A,Tejpar S,Kalogeras KT,Mazzucchelli L,Frattini M,Cappuzzo F

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:Cediranib is a highly potent inhibitor of vascular endothelial growth factor (VEGF) signalling with activity against all three VEGF receptors. Bevacizumab is an anti-VEGF-A monoclonal antibody with clinical benefit in previously treated metastatic colorectal cancer (mCRC). METHODS:Patients with mCRC who had...

journal_title：British journal of cancer

authors： Cunningham D,Wong RP,D'Haens G,Douillard JY,Robertson J,Stone AM,Van Cutsem E,HORIZON I study group.

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:Period analysis is increasingly used to compute long-term cancer survival, as it provides better prediction of survival of newly diagnosed patients than traditional cohort analysis. However, the patient population to which period survival estimates best pertain to and which should be described in a study is ...

journal_title：British journal of cancer

authors： Jansen L,Hakulinen T,Brenner H

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:Melatonin induces apoptosis in many different cancer cell lines, including hepatocellular carcinoma cells. However, the responsible pathways have not been clearly elucidated. A member of the forkhead transcription factors' family, FoxO3a, has been implicated in the expression of the proapoptotic protein Bim ...

journal_title：British journal of cancer

authors： Carbajo-Pescador S,Steinmetz C,Kashyap A,Lorenz S,Mauriz JL,Heise M,Galle PR,González-Gallego J,Strand S

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:The 1997 international consensus conference on renal cell cancer (RCC) prognosis suggested erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), and anaemia as prognostic biomarkers, but most studies reviewed were limited by small sample sizes. METHODS:The Cox proportional hazards model was used...

journal_title：British journal of cancer

authors： Choi Y,Park B,Kim K,Jeong BC,Seo SI,Jeon SS,Choi HY,Lee JE,Lee HM

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5'-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1. METHODS:The expression of LKB1 was dete...

journal_title：British journal of cancer

authors： Duivenvoorden WC,Beatty LK,Lhotak S,Hill B,Mak I,Paulin G,Gallino D,Popovic S,Austin RC,Pinthus JH

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:In this study, we evaluated the possibility that KRAS mutational status might be predictive of oxaliplatin (OXA) efficacy. We also explored the role of excision repair cross complementing group-1 (ERCC-1). METHODS:Ninety anti-epidermal growth factor receptor-naive advanced colorectal cancer patients were re...

journal_title：British journal of cancer

authors： Basso M,Strippoli A,Orlandi A,Martini M,Calegari MA,Schinzari G,Di Salvatore M,Cenci T,Cassano A,Larocca LM,Barone C

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQoL) comprises different domains of physical, mental, and social well-being. In this analysis, we focus on sexual quality of life in Hodgkin Lymphoma (HL) patients. METHODS:Four-thousand one-hundred and sixty patients enroled in the HD10-HD12 trials underwent HRQoL assessme...

journal_title：British journal of cancer

authors： Behringer K,Müller H,Görgen H,Flechtner HH,Brillant C,Halbsguth TV,Thielen I,Eichenauer DA,Schober T,Nisters-Backes H,Fuchs M,Engert A,Borchmann P

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:Multiple myeloma is a plasma cell disorder that is characterised by clonal proliferation of malignant plasma cells in the bone marrow, monoclonal paraprotein in the blood or urine and associated organ dysfunction. It accounts for approximately 1% of cancers and 13% of haematological cancers. Myeloma arises f...

journal_title：British journal of cancer

authors： Jones CI,Zabolotskaya MV,King AJ,Stewart HJ,Horne GA,Chevassut TJ,Newbury SF

更新日期：2012-12-04 00:00:00

abstract：BACKGROUND:It has been a challenge to determine breast cancer clonality accurately. The aim of the present study was to assess methods using formalin-fixed paraffin-embedded (FFPE) tissue to differentiate new primary tumours from true recurrences that are associated with poorer prognoses and often require more aggressi...

journal_title：British journal of cancer

authors： Masuda S,Kadowaki T,Kumaki N,Tang X,Tokuda Y,Yoshimura S,Takekoshi S,Osamura RY

更新日期：2012-12-04 00:00:00

abstract：BACKGROUND:Gestational trophoblastic diseases (GTDs) are related to trophoblasts, and human chorionic gonadotropin (hCG) is secreted by GTDs as well as normal placentas. However, the asparagine-linked sugar chains on hCG contain abnormal biantennary structures in invasive mole and choriocarcinoma, but not normal pregna...

journal_title：British journal of cancer

authors： Niimi K,Yamamoto E,Fujiwara S,Shinjo K,Kotani T,Umezu T,Kajiyama H,Shibata K,Ino K,Kikkawa F

更新日期：2012-12-04 00:00:00

abstract：BACKGROUND:Pancreaticoduodenectomy remains a major undertaking. A preoperative blood test, which could confidently predict the benefits of surgery would improve the selection of pancreatic cancer patients for surgery. This study aimed to identify protein biomarkers prognostic for long-term survival and to validate them...

journal_title：British journal of cancer

authors： Xue A,Chang JW,Chung L,Samra J,Hugh T,Gill A,Butturini G,Baxter RC,Smith RC

更新日期：2012-11-20 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF)-mediated angiogenesis mediates tumour growth and metastasis. Meningiomas are primarily benign, slow-growing, highly vascularised tumours. Aside from VEGF, there is little data on the function of major angiogenic proteins in meningiomas. METHODS:The VEGFA, platelet-d...

journal_title：British journal of cancer

authors： Pfister C,Pfrommer H,Tatagiba MS,Roser F

更新日期：2012-11-06 00:00:00

abstract：BACKGROUND:There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS:We ha...

journal_title：British journal of cancer

authors： Shimwell NJ,Ward DG,Mohri Y,Mohri T,Pallan L,Teng M,Miki YC,Kusunoki M,Tucker O,Wei W,Morse J,Johnson PJ

更新日期：2012-10-23 00:00:00

abstract：BACKGROUND:The role of processed meat in the aetiology of several cancers was explored in detail. METHODS:In the time period 1996-2004, a multisite case-control study was conducted in Montevideo, Uruguay. The study included 6 060 participants (3 528 cases and 2 532 controls) corresponding to cancers of the oral cavity...

journal_title：British journal of cancer

authors： De Stefani E,Boffetta P,Ronco AL,Deneo-Pellegrini H,Correa P,Acosta G,Mendilaharsu M,Luaces ME,Silva C

更新日期：2012-10-23 00:00:00

abstract：BACKGROUND:Circulating total cytokeratin 18 (tCK18) and/or caspase cleaved cytokeratin 18 (cCK18) (measured by M65 and M30 enzyme-linked immunosorbent assays (ELISAs), respectively) are used as pharmacodynamic (PD) biomarkers of epithelial cell death in clinical trials. Having validated these ELISAs, we assessed their ...

journal_title：British journal of cancer

authors： Greystoke A,Dean E,Saunders MP,Cummings J,Hughes A,Ranson M,Dive C,Renehan AG

更新日期：2012-10-23 00:00:00

abstract：BACKGROUND:Prognosis of localised gastrointestinal stromal tumour (GIST) is heterogeneous, notably for patients with AFIP intermediate or high risk of relapse, who are candidates to adjuvant imatinib. We hypothesised that gene expression profiles might improve the prognostication and help to refine the indications for ...

journal_title：British journal of cancer

authors： Bertucci F,Finetti P,Ostrowski J,Kim WK,Kim H,Pantaleo MA,Astolfi A,Polkowski M,Birnbaum D

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Radio- and chemotherapy (RT/CT) resistance hampers success in combating small and non-small cell lung cancers (SCLC/NSCLC). The underlying molecular mechanisms of RT/CT resistance of LCs are multifactorial and have been understood in part hitherto. miRNAs, key regulators of mRNAs, are well-recognised oncomir...

journal_title：British journal of cancer

authors： Salim H,Akbar NS,Zong D,Vaculova AH,Lewensohn R,Moshfegh A,Viktorsson K,Zhivotovsky B

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Glomerular filtration rate (GFR) is used in the calculation of carboplatin dose. Glomerular filtration rate is measured using a radioisotope method (radionuclide GFR (rGFR)), however, estimation equations are available (estimated GFR (eGFR)). Our aim was to assess the accuracy of three eGFR equations and the...

journal_title：British journal of cancer

authors： Craig AJ,Samol J,Heenan SD,Irwin AG,Britten A

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening. METHODS:Participant...

journal_title：British journal of cancer

authors： Kapidzic A,Korfage IJ,van Dam L,van Roon AH,Reijerink JC,Zauber AG,van Ballegooijen M,Kuipers EJ,van Leerdam ME

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Ovarian cancer is frequently advanced at presentation when treatment is rarely curative. Response to first-line platinum-based chemotherapy significantly influences survival, but clinical response is unpredictable and is frequently limited by the development of drug-resistant disease. METHODS:We used qRT-PC...

journal_title：British journal of cancer

authors： Smith G,Ng MT,Shepherd L,Herrington CS,Gourley C,Ferguson MJ,Wolf CR

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient. METHODS:The effect of TMZ on medulloblastoma (MB) cell killing was analysed with clonogenic survival assays. Expression of DNA repair genes and enzymes...

journal_title：British journal of cancer

authors： von Bueren AO,Bacolod MD,Hagel C,Heinimann K,Fedier A,Kordes U,Pietsch T,Koster J,Grotzer MA,Friedman HS,Marra G,Kool M,Rutkowski S

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Selecting patients with 'sufficient life expectancy' for Phase I oncology trials remains challenging. The Royal Marsden Hospital Score (RMS) previously identified high-risk patients as those with ≥ 2 of the following: albumin <35 g l(-1); LDH > upper limit of normal; >2 metastatic sites. This study developed...

journal_title：British journal of cancer

authors： Ploquin A,Olmos D,Lacombe D,A'Hern R,Duhamel A,Twelves C,Marsoni S,Morales-Barrera R,Soria JC,Verweij J,Voest EE,Schöffski P,Schellens JH,Kramar A,Kristeleit RS,Arkenau HT,Kaye SB,Penel N

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:There are currently two million cancer survivors in the United Kingdom, and in recent years this number has grown by 3% per annum. The aim of this paper is to provide long-term projections of cancer prevalence in the United Kingdom. METHODS:National cancer registry data for England were used to estimate can...

journal_title：British journal of cancer

authors： Maddams J,Utley M,Møller H

更新日期：2012-09-25 00:00:00

abstract：:Throughout the world there are problems recruiting ethnic minority patients into cancer clinical trials. A major barrier to trial entry may be distrust of research and the medical system. This may be compounded by the regulatory framework governing research with an emphasis on written consent, closed questions and con...

journal_title：British journal of cancer

authors： Symonds RP,Lord K,Mitchell AJ,Raghavan D

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:Around 60% of women ≥ 80 years old, in the UK do not have surgery for their breast cancer (vs<10% of younger age groups). The extent to which this difference can be accounted for by co-morbidity has not been established. METHODS:A Cancer Registry/Hospital Episode Statistics-linked data set identified women ...

journal_title：British journal of cancer

authors： Lavelle K,Downing A,Thomas J,Lawrence G,Forman D,Oliver SE

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:Inhibitors of the mammalian target of rapamycin (mTOR) might become a novel tool to treat advanced prostate cancer. However, chronic drug exposure may trigger resistance, limiting the utility of mTOR inhibitors. METHODS:Metastatic potential of PC3 prostate cancer cells, susceptible (PC3(par)) or resistant (...

journal_title：British journal of cancer

authors： Tsaur I,Makarević J,Juengel E,Gasser M,Waaga-Gasser AM,Kurosch M,Reiter M,Wedel S,Bartsch G,Haferkamp A,Wiesner C,Blaheta RA

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:We performed a cross-sectional study in Indonesia to evaluate the performance of a single-visit approach of cervical cancer screening, using visual inspection with acetic acid (VIA), histology and cryotherapy in low-resource settings. METHODS:Women having limited access to health-care facilities were screen...

journal_title：British journal of cancer

authors： Vet JN,Kooijman JL,Henderson FC,Aziz FM,Purwoto G,Susanto H,Surya IG,Budiningsih S,Cornain S,Fleuren GJ,Trimbos JB,Peters AA

更新日期：2012-08-21 00:00:00